Professor Shepherd must call together a group of awesome dogs to stop General Parvo from gaining an important weapon. Shepard names his dogs the "Road Rovers," and they set off on their first mission: to duel the General Parvo, his Lieutenant Groomer, and the first two Cano-Mutants.

The Rovers have to find a stolen device that could destroy the world. They are pitted against a new enemy, Captain Zachary Storm, a militant who was discharged from the military and is now out for revenge.

When a sceptor is stolen, the Road Rovers attempt to create a peace between two warring countries with the aid of a pack of wolves by embarking on a mission to recover the sceptor without getting themselves caught.

After discovering an amazing tool, Parvo goes back in time in the form of a cat! He becomes the pet of Professor William Shepherd, who is just perfecting his Trans-Dogmifier. Parvo plans to derail Shepard's ideas, thus ruining the future of Road Rovers! Parvo's past is revealed as the Rovers hunt him down.

A deep declining decrease in the world currency/gold market sends the Rovers out on a mission to recover the gold in South America. They meet a young boy who happens to be blind. His dog has been stolen by mutant pirhana fish. Will they save him?

Ever wondered how the Rovers manage their lives? The Road Rovers go out on a normal day of missions. It is discovered that Hunter carries with him a photo of a beautiful female dog, whom the Rovers assume to be his girlfriend. Who is she?