Following her recent experience in the mountains Claire is back to her jobs of taking care of Yoma, accompanied by Raki. In the light of her recent change in personality Claire has been given a job to hunt down another Awakened One, North to the village of Gonahl. As she reaches the rendezvous point, Claire is greeted by a lone Claymore and to her surprise it is non-other than the Claymore who lust for blood and battle, no.4 "Ophelia".

Awakened Beings have launched a surprise attack on the city of Pieta, forcing the teams of Claymores to begin their battles against these unbeatable creatures. Even with these incredibly powerful Awakened Beings to fight against there may be some Claymores who are able to handle this sort of situation, which will only get tougher in the future.