Florabelle Campbell, the valley's beauty while Uncle Joe's was growing up, is coming to stay at the Hotel. News of her visit quickly spreads among her former suitors, including Uncle Joe, Sam and Ralph. They all believe that they can rekindle their romances with Florabelle. When Florabelle arrives, she doesn't remember either Joe or Sam. It takes Betty Jo to jog Florabelle's memory. They all then have a wonderful evening.

Jeff Powers is looking for a big story in his final week working as a reporter for the Hooterville World Guardian. He misses what may be the biggest story to hit Hooterville when Sam and Joe are held up by an armed masked bandit at the store. Joe is certain that he could identify the bandit if he saw him again. What Uncle Joe and the rest of the family are unaware of is that newly checked-in hotel guest Mr. Lawson is the bandit. Joe bad mouths Pixley's Sheriff Crandall for not doing enough to stop the bandit. The bank in Pixley is next to be robbed. Sheriff Crandall decides to deputize Joe. Uncle Joe's newest labor saving device at the hotel, a rubber life raft and a hat pin may be just what he needs to catch the crook.

Sam has decided to remodel the general store. It will be closed for five days while he goes on vacation. Sam decides spend his time at the Shady Rest. Joe is excited to have all this time with his best friend. But what Joe doesn't account for is that Sam may have plans of his own. Sam ends up spending most of his time helping Helen around the hotel. When Sam finds out on day four why Joe has been in a bad mood, Sam tries to make it up to him all in one day, even if it kills both him and Joe.

In this valentine to Kate Bradley the citizens of Hooterville pull out all the stops to welcome Kate home, including a parade with floats, songs and fireworks. But first, arguments begin about where her official welcoming celebration will take place and who will preside over such an event. Mayor Potts wants to preside over it at a downtown location. Sam wants to preside over it outside his store. Selma wants to preside over it in her garden. And Joe wants to preside over it at the Shady Rest. They all wait for Kate's three o'clock arrival in front of Sam's store. Then they read her message to Uncle Joe and realize that Joe didn't read the part that said she will be arriving in Pixley. Amid the chaotic festivities, Kate muses "There's no doubt about it, I'm home.

Ted Swift, a booking agent, hears the Bradley Sisters singing on the radio. He wants to book them for the season opener of the Buddy Buster television program. After Sam shows him a photo of the girls, Ted signs a contract with Uncle Joe for the girls' appearance. What Uncle Joe forgets is that Betty Jo's pregnancy is not exactly television friendly. When Ted sees Betty Jo, he knows that he is in a bit of a bind with days until the show, and Uncle Joe can't renege on the contract as he has already spent the advance. At the performance, the girls use some creative moves to hide Betty Jo's condition, but things don't go as planned.

Doc Stuart surprises the people of the valley by announcing that he is going into semi-retirement. He will work part-time and is hiring a new associate. Doc Stuart is as surprised as anyone when Dr. Janet Craig arrives. Janet is as aware that it will be an uphill battle winning acceptance in this rural area. Indeed, those in the older generation are against a female doctor for several reasons. Joe comes up with a plan to get rid of Dr. Craig. But his plan isn't going to stop Janet from staying

Dennis Roberts, a friend of Janet's, arrives in the valley. Janet seems happy to see him, but is somewhat nervous about his visit. She knows he is there to ask her to marry him, and she is not sure how she'll answer him. If she says yes, it means she will be leaving the valley. No one wants to see Janet leave and they try to come up with a plan to make her stay. In the end, they decide to just tell her how they feel.

Janet's friend, Adelle Colby, arrives in the valley. Sam, Bert and Uncle Joe are each attracted to her. Adelle, a librarian, is in the valley to open up a new library. They have the books and the money, but now need a location. Janet suggests a mobile library in the form of the Cannonball. Sam, Bert and Uncle Joe do whatever they can to spend time aboard the mobile library to be with Adelle. This competition causes a rift between the three friends. But it's Wendell that has the upper hand in attracting Adelle's attention.

Uncle Joe announces his retirement. He learns that his big news has made him the laughing stock of the valley as everyone is saying he does nothing as it is. Feeling unappreciated, Uncle Joe decides to run away. When Janet finds out he's leaving, she tries to rally the residents of the valley to make Uncle Joe feel like he's wanted and needed. Joe sees through their plan and tries to get back at them. They then give Joe a retirement party. There he starts to feel needed and announces he won't retire.

Janet returns from a business trip with some news. She has decided to work with the famous neurologist, Dr. Pope, which means that she will leave the valley for good. The news hits everyone pretty hard and they try to think of a way to make her stay. Hopefully Ted Thorsen, the forest ranger who has just injured his ankle, may provide a romantic reason for Janet to stay. Ted is definitely interested in Janet, but she is still going to leave. But Betty Jo and Steve come up with a reason for her to stay.

Note: This was meant to be the series finale. The episode ends with Betty Jo and Steve announcing that they're having another baby. At the last minute, CBS decided to renew the series for a seventh season because it would give the series five full seasons of color episodes for syndication. When the show returned for its seventh and final season, the storyline involving Betty Jo's pregnancy was dropped and never referred to again.