The infiltration of drugs into Oz has reached unprecedented levels, and the undercover efforts of McManus and Glynn to find out who's smuggling them in backfires in a deadly way. Despite a lockdown in Emerald City, the drugs continue to trickle in—and the blame shifts from prisoners to corrupt officials.

Three generations of Alvarezes—all prisoners at Oz—are united when the partiarch, Ricardo, is found face down in his cell, suffering from Alzheimer's disease. Meanwhile, Beecher, who as Schillinger's "prag" has been forced to wear women's clothes, flips out after taking PCP.