A female jogger is found dead in Schuylkill River and Megan teams up with medical investigator Peter Dunlop to investigate her whereabouts before her murder. Meanwhile, Megan spends the day trying to solve a personal problem concerning her daughter's birthday.

When a young, interracial couple is found shot and killed inside their car in Fairmont Park, Dr. Megan Hunt promises the grieving parents that their daughter’s killer will be found. Detectives Bud Morris and Samantha Baker are ready to chalk the case up to a murder-suicide, but Megan and her team find evidence on the bodies that sends the case in an entirely different and shocking direction. Meanwhile, Peter advises Megan not to push too hard when it comes to reconnecting with her daughter, Lacey.

A magazine editor is found dead in her mansion; Megan confronts a suspect while at a social event with her mother; Ethan surprises Kate with his positive attitude.

Megan suspects foul play when a young philanthropic socialite dies; the investigation is interrupted by Kate's personal life.

The investigation into a fatal car crash reveals the seedy underbelly of a perfect-looking neighborhood.

A champion equestrian is killed and potential drug use is suspected, but when Megan's daughter, who also rides, overhears details of the case, she leads the team to a clue and possibly the murderer.

A pharmaceutical rep is found dead in the Schuykill River, but when Megan Hunt and the team investigate, there's no blood found in her body. The team must locate the original crime scene to see if they can find the cause of death, but with suspects who have access to hundreds of unknown drugs, they may never know who or what killed her.

An undercover cop is discovered murdered at a truck stop.

When a woman suspected of murdering her son is found innocent, Megan and the team try to identify the real killer; an overzealous reporter makes the investigation difficult by sensationalizing the case.

When two young girls are in a tragic car accident, one is left in critical condition and the other is found dead at the scene. As Megan and her team investigate the case, however, they realize there has been an awful mistake. Not only was the wrong girl pronounced dead, but the car accident may not have been the actual cause of death.

The team needs to quickly figure out how to treat the virus when more and more people are becoming ill and dying.