After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

After learning about what happened to Shou Tucker and his daughter Nina, the Elric brothers begin to question what alchemy really is. Meanwhile, Colonel Mustang and the other State Alchemists track down the serial killer Scar.

In a violent clash with Greed, King Bradley proves to be a brutal opponent. But the man who finally destroys the Ultimate Shield is more powerful than even the Fuhrer himself.

As Envy writhes within the firestorm unleashed by Mustang's vengeful rage, Hawkeye must take drastic measures to prevent the Flame Alchemist's hatred from burning out of control.

The light is gone. Shadows swallow everything. As the planet quakes and the heavens tremble, the souls of heroes and villains alike vanish into darkness. The circle is complete.