Ed and Al become interested in biological transmutation after witnessing a chimera in Lior, so Colonel Mustang introduces them to an expert in the field, Shou Tucker, the Life-binding Alchemist. Meanwhile, a serial killer whose targets are only State Alchemists is on the loose in Central.

After learning about what happened to Shou Tucker and his daughter Nina, the Elric brothers begin to question what alchemy really is. Meanwhile, Colonel Mustang and the other State Alchemists track down the serial killer Scar.

When Ed and Al arrive at the Central Library they discover that it has been burnt to the ground and instead are taken to see Sheska, a former employee who may have the information they seek. Meanwhile, in East City an unexplained explosion causes Colonel Mustang to restart his search for Scar.

Al is abducted by chimeras led by the seemingly indestructible Homunculus known as Greed. When Ed's rescue attempt falls short, Izumi proves once more that she's got the brothers' best interests in mind.

After learning of Hughes's fate, Ed and Al are ravaged by sadness and guilt. Envy still hides in plain sight among the State Alchemists, and another Homunculus is on the verge of infiltrating their ranks as well.

Ed's journey to a distant land of legend offers surprising new details behind Mustang's alleyway encounter with Ross. After a fateful encounter of his own, Elric learns a stunning secret about Winry's parents.

Mustang, Alphonse, Havoc, and Hawkeye split up to search a military laboratory. If Lust has her way, none of them will ever see each other alive again.

Hoping to learn more about the Homunculi, Ed and Al devise a risky strategy to lure the creatures out of hiding. Step one of the brothers' plan: risk death at the hands of their most dangerous enemy - Scar.

Even as his subordinates are scattered, Mustang finds he still has allies - unfortunately, so do his enemies. The Homunculi unleash one of the Ishvalan War's most notorious killers to deal with Scar and Marcoh.

Quiet warnings spread near and far: the Promised Day is at hand. While most will face the coming chaos with their own kind, Edward forms a new cabal comprised of human, chimera - and Homunculus.

Mustang leads a ragtag assault force of hardy northern troops - and welcome faces from the past - against Central's defenses. Victory seems certain until the military's most horrifying secret is revealed.

As one shared journey ends, many journeys begin. Those most touched by the conflict which surrounded the Philosopher's Stone now go their separate ways. One thing is certain: they will meet again.