Sam and Addison disagree over the treatment of a comatose patient who becomes pregnant; Charlotte and Pete face an ethical dilemma when a patient with HIV is in a serious car accident.

Pete finds Charlotte bloodied and bruised in the halls of the hospital, but only Addison learns the full extent of her injuries.

Despite how Charlotte is choosing to deal with the aftermath of her sexual assault, her fellow doctors think they know what's best, teaming up to pursue criminal charges against her attacker. Pete gets a surprise visitor, his estranged brother, who has come to ask Pete to help release their sick mother from prison.

Charlotte's attacker, Lee Henry, arrives at St. Ambrose Hospital, injured by his girlfriend and in need of urgent care, and Sam and Charlotte must decide whether or not to save his life. Meanwhile, Susan's health takes a turn for the worse, and Addison's mother, Bizzy, begs her daughter to do everything in her power to help.