Naomi begs Fife to use his still experimental treatment to help William's advanced ALS. Violet and Amelia treat a woman with a brain tumor, while Sheldon decides to vie for Charlotte's affections.

Maya and her unborn baby are fighting for their lives on the operating table, and Addison, Amelia and Fife try everything humanly possible to save them. Meanwhile, Sam operates on an incoming crash victim and later makes a grim discovery; Cooper makes an ill-timed but valiant effort with Charlotte, and the staff’s world gets rocked by an unexpected death.

The man responsible for killing Dell and endangering Maya's life comes to the clinic with a heart condition; news of Addison's new romance is not received well.