Violet and Cooper make amendments to their friendship in order to please their significant others; Pete and Cooper get in an argument involving marijuana use by a patient (guest starring Justine Bateman as Sydney); Addison is conflicted about going public with her new romance, and Sheldon's decision to deny approval for a patient's sex change backfires.

When a patient's partner and father are heatedly divided on his health care, Pete makes a decision that impacts everyone, including himself; meanwhile, Jake offers strength and experience to Amelia when he suspects she's being tempted to substance abuse, Sheldon and Violet treat a family concerned about the father's new sexual appetite, and as baby Henry draws Addison and Sam closer, they struggle to define their relationship.