Sheldon fears the worst when a little girl goes missing from the ER; Addison and Jake have a disagreement about one of his patients; and a new doctor joins the team at Saint Ambrose. Meanwhile, Stephanie questions Sam about his past with Addison.

A reality show centered around Sam sheds some light on issues in his colleagues' personal lives. Meanwhile, Sam's mother seeks his help after her boss falls ill; and the search continues for a girl who went missing from St. Ambros.

Upon hearing that he must meet with Henry's social worker during a home visit, Jake fears that an incident in his past will come to light. Meanwhile, Addison becomes skeptical of Jake's needy patient and James continues to pursue Amelia.

During a dark moment in his life, Sheldon finds happiness with a new woman. Meanwhile, he becomes increasingly suspicious about his patient Nick's involvement in Sarah's disappearance.