Lele is anxious to see Alice again after her declaration at the airport, but a letter sent by her seems to cast shadows on the future of their relationship. What will happen?

Lele goes to the airport for Alice's arrival, but in her place arrives a woman who Alice met in Africa and to whom she gave the ticket. There is still a wait for the two lovers, but what will happen when the time comes?

Lele decides to give Alice the ring she had bought some time before, but it seems to have disappeared into thin air. Meanwhile, the story between Cettina and Giacinto seems definitively over.

Lele's birthday but the whole family pretends to forget about it to throw him a party. Meanwhile, the doctor's relationship with Alice is being kept secret, but how long will they be able to live in hiding?

Libero would like Lele to marry Alice, but his son does not feel ready yet. Er Pasticca, a friend of Alberto's, asks him to deliver some pills, but these end up in Annuccia's hands.

Alice has organized a romantic weekend with Lele, but the latter has to go to a conference in Turin. Among her colleagues there will also be an old friend of Lele of whom Alice is terribly jealous.

Cettina asks Giacinto to meet to clarify their situation, but the latter does not appear as he is the victim of a stabbing. Cettina can't know it, and imagines that the ex didn't show up deliberately.

While at Alice's house, Lele learns that her fiancée has been receiving phone calls for several weeks from a manic admirer, who doesn't seem to want to stop there.

Libero participates in a competition to win one evening at dinner with a singer, introducing himself as They Killed Spider-Man. The grandfather takes home the victory: Max Pezzali arrives at the Martini house.

While the Martini are on the radio, Lele receives a phone call announcing that Alberto has had a car accident. Everyone rushes to the hospital and discovers a very different reality.

Alice spends more and more time at Casa Martini. Alberto feels responsible for the accident that left his friend Adriano disabled, but thanks to his uncle's help he will find the strength to go and see him in the hospital.

Lele and Alice have decided to get married and are looking for a place for their honeymoon together. Everyone helps them find it, but everyone has her own opinion and in the end they decide to go it alone.

While preparations are underway for Lele and Alice's wedding, the latter is assailed by doubts. Lele finds a letter in which the woman says she is confused and wants to think away from him.

A group of girls dressed as odalisques arrive at Lele's bachelor party, including one in particular who is very close to Lele. Alice catches him in the act, but are we sure she saw us right?

The preparations for the wedding seem to never end. The small village where Alice spent her holidays as a child was chosen for the wedding ceremony. But there is no shortage of setbacks.

Lele and Alice are finally married, but while they are leaving for their honeymoon, the woman has a miscarriage, not even knowing she is pregnant. Plans change dramatically.

Maria and Reby come up with a really good idea: to have their friends play in the garage! Will they be able to get Lele's permission? Giacinto thinks of leaving his job as a security guard and opening a shop. Will Cettina allow it?

"Pisticca" apologizes to Adriano, but will he be able to make up for it? To escape Carmelo, a very insistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to stay alone for a while?

Alice feels bad all the time and already a few people tell her that the symptoms are all there and that she could be pregnant. Instead, Lele fears that it is something serious.

Alice does the ultrasound and discovers that she is expecting twins. Lele and Alice go home to announce the news to the others, when a phone call arrives letting Nonno Libero know that his friend Fausto is in the hospital.

Nonno Libero packs his suitcase and leaves home due to the constant quarrels of his two children, who find him in a rest home. Until he learns that he has been appointed condominium administrator.

Nilde wants Lele to enter the delivery room, but the next day Lele wakes up late and arrives at the hospital when her sister has already given birth, by surprise, to a black baby.

Alice and Lele announce the sex of the unborn children to the family: they will be a boy and a girl, but the happiness is not shared by the whole family because Annuccia becomes jealous.

Alice is very anxious about the arrival of the twins, and fills the family with advice and reading manuals on birth. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Alice tries to help Maria who is facing a particular moment in her life: Roberto has asked her to make love with him, but the girl doesn't feel ready for such an important step, even if telling her is difficult.

A great job opportunity for Alice is ruined when contractions begin. Meanwhile Lele is in the hospital where Giorgi died from a post-operative rejection... Will he be able to arrive in time for the birth of the twins?

Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. Maria meets Guido at the University, a brilliant doctor who is looking for a house and will be hired by the new director at the Local Health Authority.

Maria is very fascinated by Guido, but it seems that the doctor is not interested in her at all. Meanwhile Ciccio, after a prank that risked ending in tragedy, tries to escape from Lele in Australia.

Enrica notices the growing understanding between Maria and Guido and puts a "flea in the ear" of Nonno Libero who begins to worry. Meanwhile, everyone begins to discover that Alberto has not even given an exam at the University.

Nonno Libero does not want anything to happen between Guido and Maria and does everything to keep them away. Meanwhile Alberto is depressed and sleeps in the garage to be alone. He will need the help of the family to get him out of the dark evil.

Cettina sets out to look for Giacinto, discovering a bitter truth. Maria, due to a painful episode, no longer wants to take medical tests. Will Guido be able to convince her otherwise?

Nilde is forced to close the restaurant due to poisoning and notices that Guido is the one who signed the complaint. Alberto, by improvising a nighttime radio episode, manages to get hired on a permanent basis.

A new nutritionist, Carlotta, arrives at the ASL. With her obsessive and detached behavior it is not possible to win her sympathy, and misunderstandings and disagreements arise between her and Guido. Until something brings them back together.

Guido tries to make friends with Carlotta, but the obstacle to overcome is the girl's phobia of physical contact, a difficult difficulty to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Nonno Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too calm and Antoinette doesn't understand why, so Nonno Libero invites her to take him to the ASL, to have him examined by Guido.

A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation soon escalates to near disaster.

Carlotta confesses to Guido that she is in love with him, sending him into a crisis because he cannot understand his feelings for Maria. The birthday dinner with the latter, however, skips due to a hiccup.

Maria is happy to have met Gianluca, a charming lawyer, who courts her like a real princess. Meanwhile, some kids enter Ciccio's school at night and break the pipes to skip questions and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, which carries a flag with Maria written on it. Meanwhile, Guido has gotten together with Carlotta, and everything seems to be going well... or not?

Carlotta suggests that Guido move in together, the doctor accepts. Meanwhile Maria, having broken off the story with Gianluca, has started working as a volunteer in a recovery center for drug addicts.

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.

There is a lot of news in the Martini house: Maria and Guido have been engaged for two years and Guido goes back and forth between Rome and Milan, Ciccio still plays rugby and is engaged to an English girl named Emma and…

Nonno Libero is summoned to school because Annuccia has done a decidedly strange essay on the family. Maria rents a house for her and Guido, but discovers that, for now, he is forced to stay in Milan.

Meanwhile, Guido is sad because he has to stay another two years in Milan and doesn't know how to tell Maria, who in the meantime is doing an internship at the ASL. On the way to Milan he has an accident.

Maria misses Guido very much and is thinking of continuing the university in Milan at least until she graduates. Guido meanwhile is trying in every way to get transferred, but it seems that there is no hope.

Cettina and Torello's house is now completed, but Cettina will find some nasty surprises. Maria and Guido have decided to move in together and to keep them from going far Cettina will find an unexpected solution.

The family members decide to give Guido and Maria a whirlpool and a Bohemian crystal chandelier, but the boys get angry because they would like to be the ones to furnish the house. The first quarrels arise.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Grandpa Nicola is back in style, but the reality is very different from what he wants to make it seem. He invites Maria on a cruise and she, who initially refuses, finally understands that her grandfather has only her family affection left.

Between friends and family, at Guido and Maria's house you can't find a moment of peace, and this certainly doesn't do the couple any good. Nonno Libero, on the other hand, due to a series of misunderstandings, thinks that Ciccio is on drugs.

Cettina asks Torello to let her nephew Rosalbo join the company, but one night they hear him plotting against them on the phone. The two decide to make life impossible.

Cettina doesn't know how to tell Torello that in reality she isn't pregnant because he is showering her with attention, organizing everything for the future baby. During an ultrasound, she steals footage showing triplets to play along.

Libero is worried about Olindo, an old friend of his who has been missing for days. He learns that he is in a hospice he can neither talk to him nor know how he is. Libero then asks Guido to make an inspection.

Maria has returned from the cruise and Guido immediately fills her with affection, so much so that the two are caught by the entire Martini family immersed in the whirlpool. Meanwhile, Cettina has a decidedly "horror" experience.

Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the ASL. But the troubles aren't over: the scooter doesn't work, it's a race against time.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

The ASL risks closing and all the doctors organize a protest sit-in, which will prove to be useless. Guido, on the other hand, decides to make a request to return to Milan, given that staying in Rome no longer makes sense for him.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido is looking for funding for the family hospital and decides to organize a heart game to raise funds and at the same time proposes a donation to the bank.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

After three years of absence, Lele returns to the Martini house, finding a situation that is not a little indifferent. Thanks to the help of Nonno Libero, Lele will finally be able to become a full-fledged family man again.

Lele moved to Paris, together with Alice and the twins. Guido is still in Africa with Maria. Meanwhile, Dr. Emilio Villari arrives at the Martini house in Rome to set up a new private clinic.

Alberto returns to live at the Martini house, and the family understands that his relationship is over. Cettina continues to be overprotective of her son Eros, to the point of not being able to bear the idea of sending him to kindergarten.

The Martini family meets the new Indian neighbor. Ciccio and Annuccia, after the first reticence, make friends with their grandchildren. Meanwhile, Poggiofiorito is becoming an independent municipality, and it's time for grandfather Libero to apply.

Nonno Libero is engaged in the electoral campaign against the lawyer Ulmi, who has Nonna Enrica among his supporters. The propaganda takes place with no holds barred, and culminates in a televised face-to-face.

Nonno Libero bears less and less the confusion of customers outside the Indian restaurant, and would like to close it. All the women rebel because they have started attending a yoga class organized by Kabir.

Alberto receives a letter from someone who makes an appointment with him at the mall and the boy believes it is his ex... Cettina is increasingly taken by Kabir and confesses to grandfather Libero that she can't help but think about it.

Alberto tells Ciccio that he has seen Maria, but his cousin doesn't believe him. Nonno Libero and Torello also tell the same story. The decisive confirmation will be in Annuccia's essay, which will see her sister among the spectators.

Maria goes to find Annuccia at night, leaves her a drawing and runs away, but the little girl wakes up and calls her grandparents. Libero chases after the girl, who finally no longer has to hide. But she looks very changed.

Cettina lives with Torello separately at home. Meanwhile Alberto and Ciccio go to see Maria, but the girl shows that she wants to liquidate them quickly. She confesses that she wants to forget the two years spent in Africa.

Nonno Libero goes to see Maria and tries to convince her to go home, but the girl still doesn't feel like it. But an unexpected event will make her change her mind.

After being called back by his fiancée's father, Emilio has to return to Turin for good. During a dinner with Sarita, the two believe they will never see each other again and so, from a kiss, passion is unleashed.

Emilio declares his love for Sarita, but the girl fears that they will end up hurting each other. Meanwhile, Torellhonor seems to be bankrupt, while Maria decides to offer herself as a waitress at an Indian restaurant.

Torellhonor is on the verge of bankruptcy. Meanwhile Sarita and Emilio, after having convinced an Indian couple not to practice abortion, decide to open a counseling center for non-EU women.

Cettina is forced to remove Eros from the expensive private kindergarten and take him to the municipality one. Alberto discovers that his father has cancer and he has only a few months left to live.

Alberto discovers that chemotherapy has not had the desired effect on his father. However, the boy decides to indulge him in the desire to live peacefully the time that remains to him. Cettina asks the Martinis for hospitality.

Big party at Indian restaurant. Ciccio, Annuccia, Saju, Sarita and Maria offer themselves as dancers and enliven the evening. Maria is elected "Queen of the party" and finally confides her secret to Sarita.

Ciccio and Miranda decide to flee and take refuge in a farmhouse in the countryside, owned by the parents of a mutual friend of theirs. Everyone is worried, but thanks to the intuition of little Eros, Nonno Libero knows where to look.

At the outpatient clinic they are all gathered to wait for the announcement of who will be fired, but everyone is amazed to read that Emilio has resigned to save his colleagues.

Sarita accepts Emilio's marriage proposal, but Indian tradition requires the groom to go to the bride with his parents and ask her family for her hand. Libero and Enrica offer to accompany him.

Sarita tries to convince Kabir to accept Emilio, but he is against it because according to his mentality it is very important to respect the traditions. The girl then decides to leave her house and goes to stay with the Martinis.

Sarita and Emilio have to keep the intrusiveness of their respective families at bay: Enrica would like to organize a big wedding, while Kabir a traditional Indian party.

To save the clinic, Emilio proposes to buy it with colleagues and patients, all becoming owners of a small share. Meanwhile, stag/hen parties are organized for future spouses.

Ravi's arrival at the Indian restaurant creates confusion, also because Kabir doesn't have the courage to reveal to him that his niece will soon marry Emilio. As if that weren't enough, the young man shows up at Sarita's clinic.

Maria falls ill with mumps and can no longer discuss the thesis to prevent the girl from waiting another three months, since she can't wait to go back to Africa to see Guido. To resolve the situation, the family makes a plan.

Ravi gives the girl a letter from his father, written 25 years earlier, in which he claims to have promised his daughter in marriage to repay him for a theft. She refuses to marry him, so Ravi orders her to pay off her debt.

Sarita has decided to marry Ravi. Maria lets slip with Emilio the reason why the young Indian left him. The latter goes to the hotel to Ravi and assaults him. Maria finally manages to defend the thesis and graduate with 110.

Many returns to Casa Martini: Guido has returned to his experience in Africa, Lele returns with the twins. Absent instead Cettina and her family: the former housekeeper Martini has apparently disappeared in a shipwreck.

A nasty surprise awaits Guido and Maria: in fact, the two discover that the tenant of their apartment does not want to return the keys. During a chat, Nonno Libero reveals to Lele that he feels the weight of her old age.

Grandpa Libero left, it's up to Lele to look after the whole family. Elena and Bobò are anxious about their first day of school. Annuccia continues to behave rather arrogantly towards her younger brothers.

Maria is entrusted with the case of a little girl hospitalized for some stomach pains probably due to the absence of her grandfather, who left on a long journey. Maria discovers that the truth is much more painful.

Fanny and Maria become friends, but Maria is jealous because she fears that Fanny will flirt with Guido. She does not imagine that the young colleague is interested in another member of her family: her father.

Maria's pregnancy proceeds and cravings also arrive. Meanwhile, a child neuropsychiatry department will also be opened at the clinic, which is precisely the specialization of the young doctor.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile Guido is refractory to the idea of starting a relationship with his newly found mother. Fanny discovers toxic waste dumped in a river.

Guido and Ave have a tough confrontation and the latter makes the fact that she hasn't been there in times of need increasingly weigh on her. Giulio wins the trio in the lottery and an unexpected snow in Poggiofiorito decorates Christmas day.

Maria prepares an exclusive evening for her and Guido, who is forced to stand her up. She feels a bit excluded from Guido's life since she is expecting a baby, and is convinced that he no longer likes him since he has a big bump.

As the last months of pregnancy approach for Maria, Lele feels that becoming a grandfather will be a new adventure, completely different from being a father. All the more reason because Mary's waters break early!

Nonno Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she is really in love with her.

Giulio convinces Nonno Libero to participate in a new program, Cambio Nonno. Libero accepts and finds himself with a new family, moreover, from Lazio. As a result, that family's grandfather moves in with the Martinis.

The twins notice the silhouette of a woman behind the window of the Torello house and believe that it is the ghost of Cettina. Nonna Enrica, in this regard, organizes a séance to evoke her together with her friends.

A friend of Annuccia surprises Fanny and Lele. Annuccia, after finding out from her friend, doesn't accept her father's new girlfriend, unlike the family who are still a bit confused.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Fanny decides to introduce Lele to her family. She has received permission from the Martinis to move into their house, because the maid Melina is unable to look after the child alone.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

The Martini family is summoned by the police because an American woman asks about them. The Martinis discover that the woman is actually Cettina, even if she seems to remember nothing of her past.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

The Martini family organizes a surprise birthday for Lele, desperate because he thinks of the woman he loves. Ciccio learns that Tracy has returned to Rome. She can't resist: he goes to see her at the stables!

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

The double wedding of Nonno Libero and Ciccio is upon us and preparations are underway. Maria and Guido have to meet the lawyer for a preliminary interview, to talk about the separation. But will it be the right choice?