A visit from Charles V forces Henry to conceal his growing disaffection from Queen Katherine, who is the influential Spanish monarch's aunt - even as Henry comes face-to-face with the seductive Anne Boleyn for the first time.

As a reward for his denunciation of Martin Luther, the Pope christens Henry “Defender of the Faith,” but a brush with death causes the king to seek a solution to his lack of an heir. Princess Margaret marries the decrepit King of Portugal reluctantly, but the union is short-lived; Henry's desire for Anne Boleyn intensifies when Anne goes home to her family estate.

Henry is shocked when he learns that his ally, Emperor Charles V of Spain, has released France's King Francis I from prison. He's equally surprised when Anne Boleyn turns him down after offering to make her his sole mistress.

England's population is suffering, both from a lack of food and from a lethal plague called 'The Sweats'. As a result, King Henry feels depressed and not his usual, confident self. He starts having doubts about the future and his ability to rule the country. Fortunately for him, a change is coming up.

Cardinal Wolsey's fall is quick and pitiless. Stripped of office and authority, he is banished from the court and sent far from his much-beloved King. His unlikely successor is Sir Thomas More, a man unlike the overbearing Wolsey in every way but one...his loyalty to Henry.

Cardinal Wolsey is down but not yet out. Although exiled, he tries to gather last-minute support from his old enemy, Queen Katherine. She hesitantly agrees to his plan, as she finds herself in a situation similar to that of the fallen Cardinal. But their plot is intercepted by the King's new advisors and Wolsey must pay the ultimate price.