A nuclear explosion caused by Doctor Doom causes the Fantastic Four to lose their powers. Reed's efforts to restore their powers is cut short after Doom takes over the Baxter Building. The team will need the help of Daredevil to retake the Baxter Building and get their powers back.

Gorgon is searching for Medusa to return her to the mysterious Great Refuge. Johnny is forced to help her, but Gorgon captures her. The Fantastic Four discover his hideout and find the Inhumans.

The Black Panther attacks and lures the Fantastic Four to Africa. They find the Black Panther is leader of an African tribe and that they are under attack by the master of sound, Klaw.

Bruce Banner is in town, which means the Incredible Hulk is too. When the Hulk goes on a rampage, Ben gets in his way.

The Impossible Man is on the run from Super Skrull. Johnny agrees to protect him if he tells Lockjaw to teleport him to the Great Refuge to see Crystal.

Doctor Doom once again makes himself all-powerful by draining the Silver Surfer's powers. Do the Fantastic Four have any hope of defeating him this time?