The Fantastic Four recall the origin of their powers and their first battle with the Puppet Master during a Dick Clark charity show.

The Puppet Master turns the Thing against Fantastic Four, but his plans fall apart when his step-daughter, Alicia, falls in love with the Thing and sides with the team.

As Galactus' plans unfold, the Fantastic Four try to reason with him, but it proves futile. The only way to defeat Galactus now, puts Johnny's life in mortal danger. Meanwhile, the Silver Surfer sees Alicia and his loyalties begin to change.

The Fantastic Four are at a charity function at Rockefeller Center, when the building is dragged underground. It's discovered that the Mole Man is responsible and he plans for world domination.

A creature named Annihlus appears in Reed's lab, soon followed by his mortal enemy, Blaastar. The Fantastic Four learn these two enemies come from the Negative Zone and must return them before it's too late.

Doctor Doom steals the power of the Silver Surfer, becoming empowered with cosmic power. How can the Fantastic Four stop him now?