The Fantastic Four recall the origin of their powers and their first battle with the Puppet Master during a Dick Clark charity show.

The Puppet Master turns the Thing against Fantastic Four, but his plans fall apart when his step-daughter, Alicia, falls in love with the Thing and sides with the team.

Namor, the Sub Mariner, rises from Atlantis onto dry land. He encounters Sue and kidnaps her, wanting her to be queen of Atlantis.

As Galactus' plans unfold, the Fantastic Four try to reason with him, but it proves futile. The only way to defeat Galactus now, puts Johnny's life in mortal danger. Meanwhile, the Silver Surfer sees Alicia and his loyalties begin to change.

Doctor Doom steals the power of the Silver Surfer, becoming empowered with cosmic power. How can the Fantastic Four stop him now?

A nuclear explosion caused by Doctor Doom causes the Fantastic Four to lose their powers. Reed's efforts to restore their powers is cut short after Doom takes over the Baxter Building. The team will need the help of Daredevil to retake the Baxter Building and get their powers back.

The Frightful Four have arrived to destroy the Fantastic Four. They take control of Ben's mind to turn him against the team. Can the Fantastic Four overcome this threat? And who exactly is Medusa?

Reed discovers a strange ""goop"" that can affect people's emotions. It comes from the Micro Verse and Psycho Man wants it back. He captures Sue, making her into Malice, Mistress of Hate.