MacGyver returns to his home town of Mission City, Minnesota to meet up with two old friends, Chuck and Neil, so they can dig up a time capsule they buried twenty-five years before. However, MacGyver is hesitant to dig the capsule up because he is still haunted by the death of his old friend Jesse, who died when MacGyver was young. But now MacGyver has another problem to deal with. Chuck's and Neil's sons, Danny and Sean, have gotten wrapped up in a drug deal, and the dealer is after Danny. Danny takes off to hide, and now MacGyver must find him, before the drug dealer does.

When a friend of Mac's is injured in a crash, Mac agrees to test the new racing engine designed by the Phoenix Foundation. However a business rival has other plans for him, and he has someone from the inside to help him.

MacGyver gets involved in the search for an escaped serial killer. Soon he comes to the conclusion that the killer had help from another prisoner—an even more sinister man.

The young son of MacGyver's co-worker is kidnapped by the boy's father. MacGyver must go and retrieve the boy from the house of the boy's uncle—a powerful mob boss.