When MacGyver is on his way to a vacation, he takes the wrong way and ends up at a small airstrip where everybody seems to be behaving strangely. Too late, he discovers that the airstrip has been taken hostage, and he has been caught in the middle of a plane-hijacking attempt.

During a trip to visit some friends, an accident starts a fire in an oil well owned by MacGyver's friends. MacGyver and his buddy then go to fetch dynamite in an abandonned mine at great peril to themselves after they decide the dynamite is the only feasible way the fire can be put out. However, when they use it, the fire only becomes more intense. Can MacGyver and his Hellfire friend survive the incredible heat to put out the fire and save the oil buried underneath the well?

When MacGyver comes home with some important documents, he's drugged by enemy agents and told that he will die in six hours if he doesn't retrieve the documents for them. But MacGyver, using an old prisoner trick, escapes. Now the only problem is convincing someone that he's not just another drunk.

An old girlfriend of MacGyver's contacts him for help after she discovers evidence of uranium thefts from a nuclear processing plant where she works.

MacGyver is on his way out of Bulgaria with a secret microfilm, when he meets Penny Parker, a beautiful, talkative American, who is on the run from her lover, a man named Stephan Frolov. She stashes some jewels on MacGyver, thus making him a suspect, and now MacGyver and Penny must flee Bulgaria together.

Posing as a watchmaker who manufactures bomb timers, MacGyver manages to catch a master killer—Piedra—before he attempts an assassination on a high-profile target. However, Piedra isn't about to be stopped for long.