MacGyver gets involved in the search for an escaped serial killer. Soon he comes to the conclusion that the killer had help from another prisoner—an even more sinister man.

Dr. Zito returns to menace MacGyver and Murphy when he escapes after his latest sanity hearing, leaving a series of nasty clues designed to give Mac a crash course in evil.

Macgyver's reluctance to commit to a permanent relationship causes him to dream an Old West scenario where he defends three of his lady friends from some ornery outlaws as he drives their wagon cross country.