该剧讲述了平凡女生周一一原是购物频道主持人，经历了男友张诚军爱上自己好友庄静的打击之后，毅然调入濒临解散的999电台，与拥有很多怪癖的闷骚男马路搭档，主持一档收听率为零的栏目。周一一将微风当作自己事业上的假想敌，尽管她面对工作积极努力，却依然难逃电台解散，濒临下岗的命运。微风本名曹砚，虽然事业如日中天，但女友刘真离去留下的阴影在其心里始终挥之不去。周一一的活泼大方深得尤医生的喜爱，遂将儿子曹砚介绍给一一认识。两人一见面即是针尖对麦芒，搞得人仰马翻的故事。

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