When a letter from Dr. Hans reveals the story of the miraculous medicine, Yutaro joins the Peace Force in an effort to find it.

As Aoshi arrives to bring her home, Misao joins Kaoru and some friends for a final shopping spree. However, Sanosuke and Yahiko's efforts to keep an eye on the women lead to them to be mistaken for a pair of thieves.

The Water family's efforts to gain control of the Ki have left Kaoru seriously wounded.

This is the story of how Kenshin came under the wing of Soujiro Hiko the 13th, and how Kenshin became a manslayer.

Act 3 details how Kenshin lived with Tomoe and married her as a cover until his side replenished its forces to continue the rebellion.

Act 4 is about the betrayal against Kenshin, how he lived for the next few years as a manslayer, and the origin of his cross-shaped scar.