The search for the afterlife begins in the ancient city of Hierapolis, Turkey, where Gates explores a recent archeological discovery - a portal to the underworld. According to ancient Roman accounts, something within this legendary cave killed every animal that stepped inside, and it's up to Josh to figure out why.

Dr. Deepak Chopra advises Josh to investigate the phenomenon of reincarnation in India, then in Turkey, Josh explores an Islamic path to paradise, finally he returns to face a man possessed by an evil spirit.

From ancient tombs to the latest technology, humans have always been obsessed with cheating death, the Josh visits a tribe in Indonesia where people live with mummies, finally a Russian cryonics laboratory freezes humans for the future.

In the Amazon, Josh meets a shaman who takes him on an ayahuasca trip to the brink of the afterlife, then a team of investigators guide Josh into one of the most haunted places on Earth.