Meryl and Milly seek shelter in the mansion of Cliff Schezar, a wealthy man who has hired Vash as a bodyguard! Have the girls finally found the infamous gunslinger? Or is Cliff hiding something?

During a bus trip to May City, Vash, Meryl, and Milly encounter a priest named Nicholas D. Wolfwood. Before too long, the travelers finds their journey interrupted by a horde of attacking robotic spiders!

An elderly couple asks Millie and Meryl to help them protect a piece of valuable property from their rivals. With hired killers nearby, and Vash nowhere to be found, Meryl and Millie might be in over their heads.

Wolfwood meets Lina, a girl who’s having trouble with a guy who claims to be Vash the Stampede. When she’s abducted, Wolfwood must team up with an odd fellow name Erics to save her.

Vash and the gang meet a group of orphans whose parents vanished after falling victim to a strange trance. Is it Legato’s doing? Or is there a secret villain hidden among the children?

The greatest battle of Vash the Stampede’s life arrives as he faces-off against Millions Knives. One brother wants to destroy mankind. One brother must stop him at any cost.