When a bloody bride stumbles into Bronx General, Wolf races against the clock to save her and her missing husband. Ericka and Jacob fight to keep a John Doe patient in their care.

An unexpected patient crashes into Bronx General with mysterious life-threatening symptoms.

Dr. Pierce treats a patient in crisis, presenting an ethical dilemma. Dr. Wolf and Dr. Nichols disagree on how to treat a patient.

Dr. Wolf meets a pastor dealing with mysterious visions. The interns grapple with the fallout from the building collapse.