After twelve people in a small town fall victim to a mysterious epidemic Quincy and Sam are sent on a mission to identify the disease, before the victims die.

When Will Preston, a western movie star and one of Quincy's idols, is found dead Quincy clashes with Lt. Monahan over what really happened to cause his death.

Quincy is asked to cover for a GP working in a small community north of Los Angeles. There he becomes involved in a case of medical negligence after the death of a local man.

A young woman dies in a bar, apparently of a heart attack. After the autopsy Quincy is sure that something is not quite as it seems and soon discovers some unsettling facts about her husband.

After a racing car accident proves fatal for a former Grand Prix driver, Quincy's autopsy brands the crash a possible homicide.

A roundup of prostitutes follows the death of an athlete who contracted a drug-resistant strain of gonorrhea.

A top children's TV star, and a friend of Quincy's, is shocked when his son dies of a drug overdose. He had no idea his son was even on drugs and is angry when he finds out that a doctor prescribed the drugs to him. Quincy and the star, Brock, go to visit the doctor and find an enormous queue of addicts waiting outside the surgery. They are all waiting with money in hand to buy a prescription from the doctor. Quincy and Brock set about trying to shut this doctor down and to help a young would be doctor in his attempts to get some sort of drug counseling support system set up in his college.

Quincy continues in his quest to get close down Dr. Colella's surgery and stop him from continuing to issue prescriptions for drug addicts. This becomes less of a problem though after Marty Herrera, the young would be doctor, is arrested for killing Dr. Colella! Quincy doesn't believe the boy did it but finds that the evidence seems to be pointing straight at him.

Quincy and Sam have to stay late, going over work that was completed by a Medical Examiner who, it turned out, wasn't qualified for the job. This makes Quincy miss yet another date with Lynne, his current girlfriend. When they do get together she proposes to him. He turns her down because he remembers how he treated Helen, his first wife. He was always working and never spending enough time with her. Later he feels guilty and decides to go and see Lynne and propose to her himself.

Quincy investigates the death of a teenager who smoked marijuana treated with a chemical that stimulates plant growth.

Quincy and Danny go to the tack and, while there, see a horse go wild in the stables. The horse kills one of the jockeys but, after completing his autopsy, Quincy thinks that it wasn't an accident! That someone murdered the man and tried to make it look as if the horse killed him. The problem Quincy has though is to actually prove his theory, and not even the purchasing of some horse hooves and the unusual step of autopsying a horse can help him. Though Asten has fits about the cost of both these steps to find the truth!

The small nation of San Christos has a new progressive, America friendly, president. His hold on power is fragile and he could be toppled if the rumor of an American supplied Diphtheria vaccine is killing the children it is supposed to be saving.

Quincy and Sam are sent to the country to find out the truth and save the children, if they can.

Quincy doesn't believe Monahan's theory that a teenager pushed his pregnant girlfriend to her death. Kenneth Watson: Charles Aidman. Monahan: Garry Walberg. Jeff Cavanaugh: Bill Beyers. Asten: John S. Ragin. Lorraine Watson: Dolores Mann. Sam: Robert Ito. Cathy Watson: Jennifer McAllister. Cavanaugh: Jack Rader. Mrs. Cavanaugh: Mimi Cozzens. Dr. Maslin: Paul Richards.

Quincy has to autopsy a man who died at the county hospital. He is amazed at the ability of the Dr. who tried to save him. It turns out though that the patient was originally taken to a different hospital that turned the ambulance away because the man did not have any insurance.

Quincy visits the hospital and, after seeing the same thing happen again, decides to make sure that the owner, Dr. Rollins, does not get to buy another local hospital and run it the same way.

After Quincy's traces an old man's death to his son's physical abuse he is faced with a similar case involving the exploitation of two elderly women by their unscrupulous nephew.

A nurse seeks help from Quincy when a heart-attack victim dies at the medical center where she works. Her boss and the two doctors involved want her help in trying to cover up the true circumstances of what happened. She fears for her job if she doesn't help and her career if she does.

Two old Korean war buddies of Quincy's, Charlie and Max, have an accident in one of the planes owned by their company. Although the most badly injured of the two should have survived for some reason he dies in hospital. The police think that Charlie could have killed his partner because of another, bigger, company wanting to buy up theirs and Quincy sets out to prove that he would not have done such a thing to his best friend and partner.

Three deaths due to food poisoning are linked to a football stadium where a big championship game is due to take place. Quincy has three days to find the source before 90,000 spectators come to watch and are put in jeopardy.

A father finds his son dead, having taken a drug overdose. Knowing this will affect his wife he decides to report it as an accidental drowning. Quincy's friend Volmer is the local coroner and politics lead to him not being able to autopsy the boy. He asks Quincy to help him out.

If that was not enough he also has to deal with a textile mill boss who refuses to fix irregularities at work and when an accident happens wants to hide the truth.

An explosion kills a man who is discovered to be the advance scout for a hitman. Quincy is in a race against time to find the assassin and thwart the plot to kill a government official at a hotel convention.

Sam and Quincy are attending a job fair for students when a woman falls down an escalator, just after shouting at someone who has been following her. While she is in hospital it is discovered she has a severe case of posttraumatic amnesia. A high price assassin is caught in her hospital room not long afterwards and leads to even more interest in who she is and why someone would want her dead.

Quincy and Janet finally get some time off and go on a weeks cruise. They are looking forward to some rest and relaxation together.

Before long their holiday is interrupted. Quincy is visited, late one night, by the captain. One of his crew has been murdered and he would like Quincy's advice. The murderer is caught but he has died before the morning and an autopsy reveals that he could have died from an infectious disease. A disease that could already be spreading throughout the ship!

With the cruise ship being prevented from docking at any of the islands in the area it is down to Quincy and Janet to find out exactly what the disease on board is before everyone on the ship finds out and starts panicking.

A man is knocked down and killed by a drunk driver. Quincy is outraged to discover that the killer is likely to get away with a light sentence and tries to change things. His digging uncovers much more than he, and the prosecutor, could ever have expected.

A nineteen-year old boy, with a malignant tumor, dies in a car accident. Quincy does the autopsy and meets the family. He goes to meet Dr. Pendleton, a doctor who deals with people who are close to death, and wants to learn how to deal with people who have just identified a loved one in a more dignified way. He spends some time with the doctor and even takes his place for a while.

A truck driver dies just days after being splashed by a caustic chemical he was illegally dumping. Quincy uncovers the cause of his death and investigates further, trying to find where the chemicals were dumped before it rains and a dangerous chemical cloud is created.

A family is violently murdered in their own home. The man arrested is the son and brother of the family members. He is a schizophrenic who blames everything on ‘The Beast', an alter ego inside his head who can take him over if he stops taking his medication. Quincy thinks, after talking with the DA, that he could be making it all up to get off on an insanity plea and tries to prove his theory.

Quincy is going to be testifying in the appeal of a big mob boss, Victor Ramsay, and his evidence is vital to him staying in prison. Ramsay and his people have other ideas though and have a plan to guarantee his release. They kill the only witness and then set about making sure that Quincy is discredited. Once this is done Quincy and the D.A. have three weeks to come up with more evidence or Victor Ramsay will be released.

When a young girl is killed in a drive by shooting a young 14 year-old boy is quickly arrested. The boy, Ethan, was part of a special program trying to get kids out of gangs and trouble. Ethan denies having had anything to do with the shooting, but if he doesn't tell who did do it or if Quincy and the probation people cannot find them then not only will he end up in prison but the special program will be closed down.

Quincy has to testify in the court of a small town. The witnesses in the case are pressurized into lying and Harry Muller, a bullying murderer, goes free. Within half an hour of the court case having been dismissed Harry Muller is found dead. The six men in the shop where he died all say they killed him, firing one shot each from his gun. The police chief is happy to call the death self defense but Quincy knows that it was murder and insists he will find out which one of them really killed him.

Michael Moroshima, a cop working undercover with the Asian task force and Sam's best friend, is killed while listening in on a deal between the Yakuza and the Mafia. Sam explains to Quincy all about the Yakuza and the Japanese code of honor that means his friend's father will try to find his son's killer and exact revenge. Sam tries to prevent this from happening but finds himself getting into deeper trouble himself.

Quincy and Emily's wedding is fast approaching and there are many things that still need arranging. Emily has brought in Winslow, a wedding arranger to help. While the wedding arrangements are proceeding a body comes into the coroner's office, an old man who died of natural causes in a rest home, just after his 65th wedding anniversary. After the autopsy the wife of the deceased man, Edna, comes in to see Quincy and tells him that she killed her husband.

Emily calls off the wedding when Quincy fails to make it to the rehearsal, the last straw as far as she is concerned. Quincy seems to be more interested in the tales Edna has to tell about her husbands' death. Was it murder as she claims or are her statements just the ravings of a mad woman?

Quincy and Emily receive the use of a Judge friends' mountain cabin for their honeymoon. They picture a long romantic week alone, skiing and sitting in front of an open log fire. When they arrive they are disappointed to find that there are other guests as well. All the guests are involved in law enforcement of some form or other and all know each other. They soon realize that the last time they saw each other al together was on when they all worked on the same case, a year ago. The man they all helped convict escaped jail and has never been heard of or seen since. When the judge doesn't arrive they all decide to go out looking for him in case there has been an accident. When they find his car, caught up in a snowdrift blocking the only way down the mountain, and his body inside it they all begin to worry whether the missing criminal is planning his revenge.