Team Gurren must find their way out of a strange underground village where Gunmen are worshipped as divine beings.

Thymilph, one of the Four Divine Generals of the mysterious Spiral King, arrives to support Viral's Enki, with the massive mobile Gunmen fortress, the Dai-Ganzan. Kamina and Simon pilot the Gurren-Lagann against seemingly overwhelming odds.

The Gurren-Lagann and the Arc-Gurren join together to form the massive Arc-Gurren-Lagann and stop the Human Annihilation System.