Team Gurren must work together with the eccentric Black Syblings to take down a Beastman foe on empty stomachs.

Continuing to the Gunmen rallying point, Team Gurren finds themselves on a strange hot springs getaway.

Nia true identity is revealed, as she flaunts her authority to get rid of another one of the Four Divine Generals, Adiane. The members of the Great Gurren Brigade are now suspicious of Nia and her true intentions, but she is only concerned about the depressed Simon. Adiane later returns to finish them all off, with Lordgenome's blessing.

The last of the Divine Generals fall, and the city of Teppelin collapses, revealing a Gunman of gigantic proportions. Simon and Nia struggle to pass through it in order to confront her father, the Spiral King himself.

As Simon arrives in prison, he unexpectedly meets Viral, who comments on how far he has fallen. Meanwhile, the truth about Rossiu's emergency plan and the consequences for those left behind on Earth are revealed.

At last, Simon and Nia are reunited, and by combining the power of its members, Team Dai-Gurren creates the galaxy-sized Tengen Toppa Gurren-Lagann, and engage the Anti-Spiral threat in a decisive battle to determine the fate of the universe.