A devastating bus crash impacts heavily on the MRU team. Adam's past affects his treatment of a mentally ill patient. Von becomes the meat in the sandwich between Adam and his mother.

Frank's intern program gets off to a shaky start with the ED's newest recruit giving Frank more than he bargained for. Meanwhile, Adam's sent into a spin when his mother turns up wanting to start over and a father and daughter's lives hang in the balance when a weekend away turns to tragedy.

When a patient's life is destroyed by alcohol, Gabrielle pushes Steve to a decision that will have a devastating result. Meanwhile, a new intern reveals her hidden skills to Frank when she intervenes to save a surfer from paralysis, and a young patient's well laid plans are threatened by a devastating illness, causing Bart to reassess his life.

Adam faces death when mindless violence spills into the All Saints ED. Meanwhile, Frank accidentally discovers the appalling secret Katerina is carrying and Von is presented with the opportunity of re-evaluating her relationship with Adam when she deals with a grief-stricken mother.

Jo is pulled out of her comfort zone when she falls for Declan, a stuntman at the centre of an accident involving multiple injuries. Steve comes under fire when he fails to notice a patient under his care has critical injuries. Frank is forced to question his motivation for helping Katerina. Von makes a heartbreaking decision where Adam's welfare is concerned. Amy and Bart are affected by the plight of a young woman who suffers from an extraordinary illness. Charlotte helps an elderly patient realise that sometimes the worst things that could happen, turn out to be the best.

Katerina goes to drastic lengths to win back Frank's approval. A tragic accident makes Jo reassess her priorities.

Gabrielle is forced to confront her worst fears when her father suffers another heart attack. Bart is mortified when Amy comes up with a controversial solution for a patient who looks likely to die a virgin. Jo reveals to Mike and Steve the reason why she wants to leave the MRU. Adam is once again about to be hurt by the mother he has only recently reconnected with.