Terri's mother, Eileen, asks her for help when her husband (Terri's father), Ryan, bashes her. Eileen refuses to go to hospital and Terri asks Mitch to come to her flat to treat her. Mitch discovers Terri has never talked to her mother about the domestic violence. He urges her to persuade Eileen to leave Ryan. Terri tries, but all the years of pretence make it impossible for mother and daughter to be honest with each other. Terri thinks she can try again in the morning but when she gets up she finds that Eileen has gone home to Ryan.

Working a night shift, Von nurses Lillian Gehler, who has been in a car accident with her husband. Lillian is told her husband is in the Intensive Care Unit but she continues to ask why he does not come to visit. At first Von believes the woman's disorientation and anxiety are the result of the anaesthetic but she soon realises Lillian has no short-term memory. Von and Luke learn the memory loss is a pre-existing condition and was caused by herpes simplex encephalitis, and Lillian's husband was her primary carer. Von manages to calm her patient's anxiety. When she learns that Lillian's husband has died, Von has to break the sad news and share the woman's grief. Then, unable to remember even her own grief, the patient calls for Von again and asks when her husband will be coming to visit.

Ben and Bron attend a party where a young girl has collapsed after taking a cocktail of drugs and alcohol. Her student ID card identifies her as Zoe Dell. When Ben and Bron try to get her to hospital, they are confronted by a gang of drunken youths. They call for police back-up. The girl's condition worsens and they have to treat her while under siege. Steph believes the girl has been admitted with false ID and she clashes again with Dr. Preece, refusing to treat 'Zoe' as prescribed. Steph discovers the girl is really Julie Bentham and she is allergic to penicillin. If she is given the antibiotic she could die. Julie's life is saved twice in one night.

Connor is rushed off his feet when one of his patients reacts badly to a new sedative and starts to sleepwalk. Connor chases him around the hospital all night and falls foul of the night Assistant Director of Nursing Brenda Blair.