A TV celebrity checks in for a double mastectomy — accompanied by a television crew who will document the whole procedure for a new medical show. Terri seeks to help the woman make what is an important life choice, despite the invasive presence of the media. In the midst of their latest public confrontation, Professor Craig drops a bombshell on the staff of Ward 17 — with dire consequences for her relationships with Luke and Connor. Jared's professionalism is challenged when he is tasked with caring for a homeless man. Bron is surprised by an eccentric patient's preparations for her death. Jared rejects Angie's plea for help.

The 1998 season finale is packed with emotion when Ward 17 celebrates Christmas. A sick child hopes that her Christmas wish will come true; an elderly man asks Santa for a special gift for his ailing wife; Von learns the true meaning of Christmas; a homeless man goes to great lengths to stay in All Saints for Christmas dinner and Bron is in for a surprise at the Ward 17 Christmas party. Sophie is faced with the possibility of losing custody of her children to her father-in-law. Connor has decided it is finally time to tell Bron how he feels while Jared and Jaz receive test results.

Having responded to the scene of Sophie's car accident, Ben is having difficulty coming to terms with the aftermath of treating people he knows. Sophie and her children have survived the head-on collision resulting from her impaired driving but her friends are even more shocked when her desperate actions the night before come to light. Refusing to lose custody of her children to the man who raised her husband, Sophie confronts her father-in-law from her hospital bed putting Terri and Peter in the middle of a siege situation that will change eveyone's life. Meanwhile, Bron's fundraising netball game disintegrates when some personal agendas come into play on the court and Von's New Year's resolution seems destined to go up in smoke. A comment in the OR results in a nurse filing a report against Luke for negligence.

Mitch Stevens' unorthodox doctoring style brings tension — and humour — to Terri's ward. He steps on many toes as he goes but his decisions prove to be life-saving. Ben's first day back on the job as a paramedic brings unanticipated challenges for Bron when a young mother suffers an horrific tractor accident. Samantha O'Hara suffers a crisis of confidence when she makes a diagnostic mistake which affects her budding relationship with Jared while Connor becomes the unwitting pawn in a lapdancer's manipulative game. Terri steps in to care for Peter when he dismisses his homecare nurse.

When a Jehovah's Witness patient is admitted for treatment, Terri and Luke find themselves on opposing sides of an ethical dilemma. Bron is forced to make some difficult decisions in order to save a life when she is caught up in an armed robbery. Mitch is devastated by the unexpected death of a patient despite his furious efforts to resuscitate her. Conner scores a double date with a surprising conclusion.