Jimmy, Carl, Sheen, Cindy, Libby, and Goddard blast off into space in Jimmy's newly invented spaceship to mine for aster-rubies while fighting off space bandits and their own greed.

King Goobot has organized the most diabolical collection of bad guys to ever assemble on one space station. Their mission: Get Jimmy Neutron.

When the entire population of Retroville is accidentally hit by Jimmy's shrink ray, the Space Bandits abduct everyone with the nefarious plan of marketing and selling them throughout the galaxy as living dolls.