While investigating a murder in a rural town and clashing with the local sheriff, Will uncovers surprising truths about his past. Meanwhile, Angie makes an unexpected discovery, and Ormewood continues to struggle with his diagnosis.

Unleashed by a domestic terrorist group, a mysterious biological attack runs rampant in Atlanta. As Will and his team race to contain the threat and save countless lives, he's forced to confront the complex dynamics of his own family.