Dr Burnett is called out to a run down farm house where 15-year-old Simon, who has speech and learning difficulties, is running a high fever. The farm is in a bad state and the family seem to be struggling to cope. They’re horrified when Burnett reveals he needs to get Simon to hospital ASAP in order to rule out meningitis. Will they get to the bottom of Simon’s illness?

Mr. Middleditch's 70th Birthday celebrations are interrupted by a bus crash.

With Susie and Carnegie's relationship becoming the focus of talk in the hospital, Matron reaches the end of her patience and decides to suspend Susie when she's late for work. Mr Rose faces a personal test when a golfing friend of his has to into the operating theatre, Nick copes struggles with a dilemna and Gordon and Bobby are called to a farming accident where a man is trapped by a combine harvester.

Nick races against time to save two schoolgirls who have been poisoned by carbon monoxide, Susie has to use quick thinking when Matron falls ill during their picnic on the cliff front and has to go into hospital, giving Susie an opportunity to prove herself. In the meantime, a man is training to become a priest, which causes a family problem which Jill needs to sort out.

Dr. Ormerod and Dr. Weatherill accompany Brigid back to Ireland for Moira's funeral, and uncover shocking family secrets in the process. Meanwhile, a new locum is thrown in at the deep end at the Royal.

Dr Ellis confronts local prejudice when he discovers one of his patients has contracted a rare disease abroad. Jack and Alun begin a crackpot scheme to raise chickens, Brigid makes a decision about baby Aisling's future, while Jean becomes more frustrated with Lizzie's incompetence.

Weatherill treats a schoolgirl whose crush on a teacher has spiralled out of control, while Ormerod and Ellis launch a daring cliff rescue when a family picnic goes awry. Jack and Alun use an old map to hunt for buried treasure underneath the hospital, and an old friend of Matron is taken ill.