Claude Greengrass causes a kerfuffle with a coffin containing the remains of his deceased sister and a mysterious phone call only serves to raise suspicions. Jill Weatherill has trouble with a patient who refuses to accept her condition, while Dr. Cheriton panics when he arrives at the scene of an accident bereft of vital medical equipment.

A serious coach crash throws the Royal into chaos, and for one member of the staff, the incident proves exceptionally traumatic. Cheriton has a bombshell for Nurse Taylor.

As preparations get under way for the Royal's charity ball, Ken Hopkirk is forced to rescue the band hired for the evening when their van breaks down en route. Meanwhile, Dr. Weatherill faces a traumatic time as one of her patients discovers she has contracted syphilis and Dr. Ormerod resolves to move on when it emerges that his wife will not recover from her coma.

New GP and anaesthetist Dr. Jeffrey Goodwin has a tough first day at work when he witnesses a car crash, gets attacked by one of the drivers involved and has his own vehicle and possessions stolen on his way to The Royal. After recovering from his injuries, Goodwin treats local landowner Lord Firminger who's collapsed on his estate, and gets off to a shaky start with Rose by asking him to perform emergency surgery on a cancer victim. Back at the hospital, Cheriton's mother Annette arrives to collect her dead son's things, surprising staff nurse Meryl Taylor by revealing a photo of a fiancee she never knew about.

Harper accidentally puts insect powder in his tea and Jeff wrongly orders the closure of a cafe after a jazz band is poisoned.

Goodwin comes to the aid of a man brought in with a leg injury which his friend claims was sustained in an agricultural accident, but it soon emerges that he's actually suffering a gunshot wound - prompting his panic-stricken acquaintance to pull a revolver on the hospital staff. As armed police surround the Royal, the doctors strive to persuade him to hand over the gun, but will they be able to prevent further bloodshed? Meanwhile, Ormerod helps fossil collectors hurt in a landslide, Matron tries to convince Sister Brigid to return to work and student nurse Samantha Beaumont is less than impressed at the offer of a date with Alun Morris.

Jill visits a war veteran and is taken hostage and Harper os spotted paying visits to a strange woman.

The hospital has its hands full when a typhoid epidemic breaks out in the community. Things get worse as the disease's source is traced back to the wards and staff struggle to locate it. Dr. Weatherill is forced to reprimand Dr. Ormerod after catching him sleeping on the job - but also has a startling piece of news to give him.

Due to a mix-up over the job offer two new doctors arrive at the hospital to take up the position. Meanwhile, Catherine makes her feelings clear to Carnegie about their relationship and Stella's night out ends badly.

A piano teacher (guest star George Costigan) remains suspiciously secretive about his past when brought in to casualty after collapsing outside the hospital. Matron's revelation about Susie cools Alun's interest in her, and Mike takes pity on a mother while he treats her son. Elsewhere, Jill delivers bad news to an elderly patient and the porters are forced to take industrial action in support of a colleague.

Mr. Middleditch's 70th Birthday celebrations are interrupted by a bus crash.

Mr Middleditch has come in to St Aidan's hospital, accompanied by his wife, for a routine operation. Noticing that Mrs Middleditch looks unwell, the hospital decides to give her a blood transfusion. Distracted by the attentions of a rich divorced playboy, who has promised to marry her, Susie Dixon administers the wrong blood, which later results in serious consequences for both her and the patient.

A secret from Jean’s past resurfaces when the wife of a former lover arrives at the Royal and accuses Jean of being up to her old tricks. When things take a shocking turn Jean is forced to reconsider her future as well as her past.