As the MPU struggle to adjust in the wake of tragedy, they are forced to jump into action when a muralist goes missing after painting a piece on a local rooftop; the missing person's mother reveals that he was scheduled to donate his rare bone marrow to his dying brother, who needs surgery within the next 48 hours in order to survive.

When a customs broker goes missing, MPU discovers that she is an undercover FBI informant now being forced to transport a little girl over the border to her criminal father. Jason and Mike find a tablet at the girl's last known location, and defying the FBI's orders while working alongside Lt. Gabrielle Bennett, Jason goes undercover in order to rescue both the customs broker and the girl.