Pierre Le Pew convinces Slam and Duck that Slam can become a champion fighter in his private tournament. However, he fails to tell them that the last match is to the death. It's up to the rest of the Loonatics to save Slam before it's too late.

After the Loonatics' mission on stopping Toby the Pizza Boy possessed by a Bio-Tech Brain Parasite device, Rev Runner's family comes to visit when they want Rev to take over the family business. When Rev's brother Rip finds the confiscated Bio-Tech Brain Parasite, The Loonatics must stop him.

When Rev and Lexi tamper with Tech's X3000 Automated Weapon System mistakening it for a video game, Melvin the Martian comes to Acmetropolis to destroy it after his spacecraft was hit by a missile from Tech's invention. When Melvin threatens to shrink the planet, Lexi admits she tampered with Tech's invention and Melvin orders that Lexi be handed over to him in 24 Hours. Can the Loonatics find a way to thwart Melvin before Acmetropolis becomes the only planetary location to be "hard to find on any map."

Now that Optimatus is free, he alongside General Deuce and Rupes Oberon plan to use Planet Blanc's wormhole generator to take over the universe. Planet Blanc is said to be at the center of the universe, and that every point in the universe can be instantly travled to with ease from it. The Royal Tweetums contacts the Loonatics for help. It turns out that Tweetums evaded capture. The Loonatics must find him before Optimatus does, but not without help from an old enemy.