Moments after discovering his daughter, Kimberly, has snuck out of the house, Jack Bauer is called into work. As head of the CIA's Los Angeles Counter Terrorist Unit office he's told that an assassination attempt will be made within the next 24 hours on the life of presidential candidate David Palmer and it's up to his team of agents to keep Palmer alive. Meanwhile, Jack's wife, Teri, sets out to find their daughter.

Convinced Jack needs to be relieved of his command, one of his team members, Tony, calls George Mason who arrives and puts the CTU under lock-down. With the help of his second-in-command, Nina, Jack slips out and heads for an address listed on the key card. Once there he encounters a shooter who hints that Kimberly's disappearance is part of a bigger plan. Meanwhile, the two boys deliver Kimberly to a man named Ira Gaines.

Jack follows the arrested shooter to the police station in hopes of interrogating him only to find that Mason has arrived and taken control of the situation. But when the shooter says he will talk only to Jack, Jack learns he must break the shooter out of jail in order to learn who has kidnapped Kimberly. Back at the hotel, Senator Palmer learns more about the threatened news leak that could hurt his campaign.

Jack learns that one of the assassins, Alexis Mecir, is actually Victor Drazen's son and has become intimate with one of Palmer's aides. In an attempt to find the man ordering the assassinations, the aide agrees to plant a tracking device in Alexis' wallet. Back at the safe house, Teri and Kim discover their location is no longer secret or safe.

During their escape from the safe house Teri and Kim become separated, and the traumatic events of the day result in Teri passing out and then awakening with amnesia. Assuming her mother has been re-kidnapped, Kim conducts her own search for information concerning her mother's abductors. When the plan to track Alexis backfires, Jack pretends to be Alexis in order to keep a rendezvous with one of Alexis' contacts.

Against his family's wishes, Senator Palmer decides to go public about the secret scandal surrounding his family. Even as Alexis' brother, Andre, sends another assassin to the Bauer residence in hopes of finding Teri and Kim, a confused and scared Teri meets Dr. Parslow, a man who says they are good friends. Unaware of the danger Teri is in, he offers to give her a ride home.

Alexis' contact turns out to be a power company worker who was being paid to shut off the electricity to a power grid out in the middle of an empty field. As Jack and Mason follow up on that lead, Kim's search for information lands her in jail, even as Palmer's press conference disclosure could ultimately put his own son in jail.

As Kim tries to get the police to call CTU, Jack discovers that the empty field where the power grid is located actually houses a secret underground government prison and that night's scheduled arrival is none other than Victor Drazen, the man Jack supposedly killed two years ago. Now Jack's convinced Victor's sons are coming to break him out.

Jack's fears are proven true when Andre Drazen breaks into the underground facility to rescue his father. With Jack as his prisoner Victor calls CTU, but Mason tells him he doesn't negotiate with terrorists. Desperate to buy some time, Jack tells Victor that his son, Alexis, is still alive. Back at the police station the police finally let Kim go, but her drive to CTU doesn't go as planned.

Jack has Nina connect Victor Drazen to a hospital phone so he can talk directly to Alexis. Nina then advises Palmer of the situation. Palmer urges Mason to arrange the exchange Drazen proposed: the return of Jack for the return of Alexis. Although Alexis is delivered, Drazen holds onto Kim and tells Jack he needs to do one last thing if he wants to see his daughter again.

Jack arrives at Palmer's hotel with a phone on which Drazen will call and ask Palmer to unfreeze $200,000,000 of his assets. When Palmer tells Jack that Drazen knows that's impossible, Jack grabs the phone and throws it off the balcony. It explodes seconds later. Realizing Drazen will never give up, Jack suggests having the television report that Palmer died in the explosion, leaving Jack to offer himself up in exchange for Kim.

When Jack arrives at Drazen's location, he calls and asks to speak to Kim. Andre angrily refuses and says that they known Palmer is not really dead. Stunned, Jack hangs up and immediately calls Nina to tell her there's still a traitor inside CTU. Momentarily uncertain how to proceed, Jack is suddenly shocked into action when Nina calls back with tragic news.

It's been a year since Jack lost his wife, and the emotional toll includes estrangement from his daughter Kim, who is now a live-in au pair for a troubled family. Jack is no longer with CTU, and no longer interested in that line of work - until he's summoned directly by President Palmer. The situation: terrorists have planted a nuclear device somewhere in Los Angeles and plan to detonate it within 24 hours.

Jack reestablishes his undercover identity to join a crew of suspected terrorists that may know something about the nuclear device planted in Los Angeles. Posing as career criminal Jack Roush, his only hope in proving his loyalty to them lies in the package he's carrying. Meanwhile, President Palmer deals with a curious press, including one particularly skeptical reporter; Kim tries to protect Megan from her father; and Kate Warner follows up on suspicions about her sister's fiancé.

Jack tries to undermine Eddie's mission to bomb CTU while George investigates intel leading him to the site of the nuclear bomb's construction and Kim tries to make contact with her father by heading for CTU headquarters.

George returns to CTU where he orders the medics to revive a badly injured Paula, who has vital information. Palmer comes down hard on Eric for his deception. Kim takes Megan to the hospital, but the staff accuses her of abuse. Jack locates the leader of the American terrorist cell. He learns that the woman who gave them inside information on CTU is an old enemy.

George refuses to allow Jack to assist in Nina's interrogation. Jack resorts to blackmail to change George's mind. Palmer and Stanton meet with a Middle Eastern ambassador who may be in league with Second Wave. Tony visits the Warner home and questions Reza about his possible connection with Syed Ali.

Jack begins his interrogation of Nina and pushes all boundaries in order to force her to divulge the name of her contact. Palmer is surprised and suspicious when his ex wife Sherry returns and claims to have information about a conspiracy against him from within his own administration. Kim and Miguel plan to kidnap Megan from the hospital in order to take her out of LA and away from the nuclear threat.

Jack forces Nina to help with a sting operation against her contact in the hopes that he can lead them to the bomb. Palmer and Mike try to gage Stanton's loyalty when they investigate the chopper crash. George has a final conversation with his son.

Kim and Miguel are arrested and the police plan to take them back to LA. Tony questions Bob Warner at CTU and learns more about his government connections. Palmer discovers a traitor in his ranks when the journalist whom he was holding is set free. Nina pulls a deadly countermove, setting herself up as the main player in the search to locate the bomb.

George pits Bob against Reza in hopes of learning which one is working with Second Wave. Sherry and Lynne clash over Palmer's speech to the press. Kate is interrogated by Syed Ali, who believes she knows too much about the bomb. Jack and Nina fight off a group of renegade soldiers while waiting to be rescued from the crash site. They nearly escape when Nina takes Jack hostage and demands to speak to the President.

Two traitors are uncovered. One is the mole in the Palmer administration who is working with Stanton. The other is the member of the Warner family who helped Syed Ali to bring the bomb into the country. Jack learns of Ali's location and tries to rescue Kate. Kim and Miguel hatch an escape plan to stay out of LA, but the results are disastrous.

Kate helps Jack to locate and identify Syed Ali. Palmer places Stanton under arrest, but he won't break. Palmer realizes he must go to extremes to make Stanton talk. Kim hits her low point of the day when she encounters a cougar in the woods.

Jack engages in a brutal contest of wills with Syed Ali. George questions Bob Warner to learn more about Marie's motivations for helping the terrorists. Kim is rescued by a mysterious hunter who offers her asylum. Lynne receives a dire warning from Sherry.

Jack and his men prepare for a confrontation with Stanton's renegade soldiers as they converge on the bomb. Kim becomes suspicious of her host, but is forced to stay because of her status with the police. Stanton finally breaks down and gives Palmer some unpleasant news.

Jack and Kate try to break Marie's resolve so they can learn the location of the bomb. Palmer confronts his ex wife with the information that Stanton gave them. George finally steps down as director of CTU and hands the position over to Tony. Kim discovers her host's deception.

Palmer, Mike and Lynne discuss various ways to dispose of the ticking bomb. They conclude that the desert is the best place to set it off. Jack determines that one man must pilot the plane carrying the bomb. He chooses to fly the plane himself and bids a tearful goodbye to his daughter. Tony and Michelle become suspicious of a Middle Eastern diplomat who is asking questions about the evidence against Syed Ali. Palmer departs for Los Angeles so he can be on hand when news of the nuclear bomb reaches the public.