After deflowering a male classmate, Jerri finds out that she has contracted a series of STDs (syphillis infested with crabs which are carrying gonorrhea) and must inform all her partners of her discovery. Meanwhile, Mr. Jellineck and Mr. Noblet have problems concealing their own bout with a particularly noticeable STD.

Jerri and class hunk Laird are having a fling, but he is insistent on keeping it a secret. So Jerri finds herself forced to hide out in odd places like Laird's locker, the trunk of his car, a trash can, etc., so they can continue their secret rendezvous. Meanwhile, Jerri's stepmother experiences relationship troubles with Stew, prompting an unusual bonding moment between stepmother and stepdaughter.