A cabin burns down in the woods revealing two bodies, one of a modern-day witch and one from the days of the Salem Witch Trials leading Booth and Brennan into the world of Wicca to find a killer. Meanwhile, when Hodgins' reckless driving gets him and Angela arrested and thrown in jail, Sweets and intern Clark Edison step into unfamiliar territory to help out the team

The team suspects that a man who made his money donating sperm was killed by a recipient who learned his records were inaccurate; Brennan enters a feud with a fellow author (Nora Dunn).

The investigation of the murder of a video-game designer reveals the wealth he accumulated during his career, which makes a suspect out of everyone who was in his inner circle. Meanwhile, "squintern" Jessica sheds light on an educational opportunity; and Brennan and Booth discuss Christine's future.

When the remains of famous billionaire explorer Henry Charles are found in Antarctica, the high profile case is brought to Brennan and Booth to determine if his death was a murder. The Jeffersonian team confirms he was killed when he went missing ten years ago on an expedition, but the timeframe puts the Jeffersonian's Dr. Clark Edison, who was with Charles for the expedition, on the short list of suspects. Meanwhile, Cam's sister comes into town to help with wedding plans and old family friction comes into the picture.