German agents question Olivia about her "relationship" with David Robert Jones, an escaped prisoner questioned months earlier now living in the U.S. The Fringe Division investigates a threatening case where victims die faceless from their orifices suddenly sealing.

The Fringe Division is on the case when severely mutilated bodies drained of spinal cord fluid begin to pile up. After their investigation leads them to a scientist with possible ties to the Z.F.T. bioterrorist cell, they are shocked to discover the identity and motive of the killer. When the kills occur with increasing frequency, Olivia, Peter and Walter go to desperate lengths to stop them.