The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.

The Sliders track down Quinn's long lost brother, Colin, to a Amish-type Earth. Quinn convinces Colin they are brothers and to slide to find their true home. But on the next world, a double of Colin's former love takes advantage of him and involves him in a scam to steal cryogenically frozen bodies.

The Sliders arrive on a Kromagg training camp, where half-human Kromaggs hunt humans. Quinn tries to convince one of them to help free a captured Colin.

Colin is wounded on a Wild West Earth and separated from the others. While he is nursed back to health by a widow and her daughter, the others search for him and find an old foe.

The Sliders arrive on a world where combustion engines were outlawed by the government due to pollution. But a biker gang is fighting to keep their engines and Mallory falls for the gang's sexy leader.

The Sliders arrive on a world where millions play in highly realistic arcade simulations. Rembrandt and Mallory take part in separate simulations, until they discover Maggie and Diana have been forced to play characters in these simulations, where each "death" experienced is real.

The Sliders confront Dr. Geiger again, in a collapsing dimension full of innocent victims.