Two dead victims show up with all the fat having being stolen from their bodies. Sam and Dean go undercover in order to investigate a local spa, and discover that a monster is preying on the overweight.

Sheriff Jody Mills is matched with an overeager partner during a mandatory sheriff's retreat and when a gruesome corpse is discovered, Jody calls Sam and Dean to help investigate.

Sheriff Donna calls Sam and Dean for help after a horrific murder with supernatural elements happens in her town. Sam continues to have visions and asks God for help, which frustrates Dean.

When Sam and Dean go missing, Jody Mills calls Claire Novak, the rebellious rogue hunter, and tells her it is time to come home – they need to find the Winchesters. Claire returns and reunites with Alex Jones, who has stayed behind with Jody and tries to balance a “normal” life with being a part time hunter. While Jody is happy to have Claire home again, she’s plagued by Patience’s disturbing vision involving her adopted daughter. Claire and Alex search for Kaia Nieves, the dreamcatcher responsible for opening the rift that Sam and Dean went through, as she holds the key to their whereabouts. Jody calls her friend, Donna Hanscum, to round out the team and the women head off on the most important hunt of their lives.

Donna calls Sam and Dean for help after her niece, Wendy, goes missing. The three hunters discover Wendy was kidnapped by a man who sells human parts to monsters in a grotesque online auction and race to save her before it is too late.

Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

With the plan in full motion, Sam, Dean, Castiel and Jack fight for the good of the common goal.