A renegade Amazon, Aresia, leads a new incarnation of the Injustice Gang to accumulate the components for a bio-weapon.

After Aquaman frees Solomon Grundy, Hawkgirl and the Justice League are convinced that the Lord of Atlantis has gone rogue. But when the trail leads them to the mysterious Dr. Fate, they discover there is more to this strange partnership than meets the eye.

With the initial ritual destroyed, the League, Fate, and Grundy must travel into the dimension of the Old Ones while Aquaman fights the invaders in the Earth realm.