While Pete and Claudia travel to Oregon to look for an artifact used to kill enemies of the environmental movement, Artie deals with the repercussions of Leena's death.

When Paracelsus takes control of Warehouse 13, it proves to only be the first step in his plan to recreate the entire world in his image. To stop him, Pete and Myka must follow him back through time to 1541 and prevent him from killing the Regents and becoming the permanent master of the Warehouses.