When Megamind's body-switching tech causes him and Roxanne to swap bodies, they must figure out how to act as the other before unleashing too much chaos and destruction on the city.

Roxanne's rekindled friendship with an old camp buddy makes Megamind jealous, so he reprograms Keiko's robot science project to act as his new best friend.

With Metro City once again thinking that Megamind is a villain, he must make his way through town without being spotted. Things become complicated when a plucky 7-year-old boy thinks he's the hero who can stop Megamind.

Megamind runs into his former nemesis Metro Man while trying to escape prison.

Megamind faces the ultimate challenge when he must square off against a mind-controlled Roxanne.