Annie has a bad cold, so what she really needs is rest, but what she gets is locked out of her apartment, as well as a request to check on a neighbor whose friends fear may be dead. Annie's flu forces her to try to spend a quiet day at home alone, but her apartment turns into Grand Central Terminal when each of her friends has a crisis and comes to her for advice. Annie's day is anything but restful when Elliot asks her to critique his latest short story, Roger finds a mole on his neck and thinks he is dying, and Didi has an emotional breakdown when Jim cancels a date.

After the heating system stops working for 2 weeks in the building, Annie organizes a rent strike with the other tenants in the building. When that backfires and the water and electricity get turned off, she goes to The New York Hall of Records, room 702-A, to try and find the name of the owner of the building from the supervisor, Mrs N. Bradstock. Meanwhile, Elliot and Gail realize their marriage is over, so Roger invites Elliot to stay at his new apartment, but the odd couple living situation is more than Roger bargains for when he ends up being mother and maid to sloppy Elliot.

When Didi lands a job assisting a famous playwright, Annie lands a date with a handsome actor and Elliot convinces Didi to show her new boss his play. Meanwhile, Roger considers mending his womanizing ways when he falls for an independent career woman who asks him out and then dumps him after only one date.