Diana locates her sister, April, who took promicin and developed an ability that puts her life in jeopardy.

Jordan wants Shawn to rejoin the movement. Meanwhile, a 4400 with an amazing ability disappears.

Jordan Collier's movement takes a huge step forward when his followers settle in the heart of Seattle.

Richard surprises Isabelle when he shows up in Promise City but the happy reunion takes a turn when Richard kidnaps her in hopes to start a new life with his daughter.

Tom and Diana must race to find the source of a computer virus that could bring down Ubient software, one of the world's largest software companies that is run by suspected member of the marked, Drew Imroth. Meanwhile, Maia visits Promise City where she receives an unexpected birthday surprise: a visit from her birth parents.

Meghan and Diana learn how to remove the entity from Tom, but the procedure is dangerous.

Meanwhile, Shawn finds help in his attempt to rescue Kevin from Promise City; and Jordan is betrayed by someone close.

Paramedics try to resuscitate Susan Farrell. They believe that she took promicin and lost the 50/50 lotto that comes with it. Danny is certain that she did not take the shot. After arriving at the hospital with the paramedics, things get complicated as everyone around Danny start to die. Garrity and another NTAC agent are sent to the hospital to assess the situation.