After being locked out of her new house all night, Dr. Caroline Todd is forced to turn up to her new job at the local hospital tired and smelling like a mini-cab after using car freshener as a replacement for deodorant. She soon meets the strange staff, but anaesthetist Dr. Guy Secretan is very welcoming and offers her his spare room for the night while he works a night shift. However after a blocked toilet incident, she soon realises Guy's true motives after he turns up home early and she discovers there isn't actually a spare room.

Meanwhile Dr. Alan Statham is having troubles of his own after someone defaced his badge by blacking out the letters O,N,S,L,T and A from his Consultant name badge, and his secret lover, Head of Human Resources Joanne Clore, tells him he isn't particularly well endowed – prompting him to check a corpse for comparisons sake.

It's eight weeks since Guy stole the ambulance and drove to a literal cliffhanger ending with Mac and Martin in tow. Mac is now in a coma and is receiving a constant stream of admiring visitors while Guy is not coping too well with the fact that he's slept with his mother. She's not having a great time of it either with her office staff's constant ribbing. However, Martin is happy to have a new brother and he's now gone as far as kissing Karen's tongue!

Statham, when not drawing breasts upon his x-rays, is trying to make Joanna jealous with increasingly desperate pretend sexual exploits. Mac is back at work and, with no help from Guy, is causing Caroline grief as he can't remember the twenty minutes that they were an item. Meanwhile, Karen and Martin have moved on to the next level and she's wearing him out.

A documentary crew visits the hospital, exciting the creative juices in Alan and the bitter rivalry between Sue and Joanna. Meanwhile, a tape of Guy being "intimate" with his mother is now in the possession of Sue who plays merry havoc with his and Joanna's life. And is this the end for Angela as she falls for the charms of the director who's off to Toronto next week?

Guy's got problems, he's looking for a place to stay while fulfilling his community service. Martin is in need of some cash so acts as a life model at an art class attended by the soon-to-be-gobsmacked Sue. Statham is distraught at his parking space while Joanna might need glasses. Mac and Caroline's relationship is hotting up but could all that change as his ex-girlfriend joins the staff?

Dr. Statham enters politics but requires a voice coach and the use of a car with two loudhailers! Martin inadvertently becomes a pimp. Mac and Caroline get a little closer but Holly sticks her oar in with a little ginger surprise for Mac. Harriet and Lyndon manage to have a date despite Joanna's best attempts to sidetrack her with work. Guy is not exactly the best flatmate but is he there at the right time for Caroline?

Mac adjusts to his new rôle as a father while Caroline tries to make him jealous with Guy. Statham is rather pleased with himself for winning his radiologist's community weekly caption competition which does not please Joanna. She employs her vertically-challenged cousin to scare him but a trip to the incinerator is soon required. Martin pesters Joanna for knowledge of his dad and hires a detective to find him.

Sue does some detecting; Martin comes into some money; Statham and Joanna try to keep the incident with the stuffed heron secret; Caroline has to be cruel to be kind.

Demented dwarf killers Joanna and Dr Statham are amazed that they seem to have got away with their hideous crime so consider themselves above the law. Caroline gets no fewer than three proposals. Sue gives birth to an infant with a mane just as impressive as Mac's. Mac gets some bad news while Martin (and we the viewer) ends up with a strange sense of déjà vu in the season's cliff-hanger ending.