Brenda and the squad investigate the murder of a hair stylist and Brenda's parents stop in for a visit on their way to Alaska.

Brenda and Fritz's attention is diverted by problems on the job even though their wedding day has finally arrived, and bad blood between the members of the Priority Homicide Division threatens to cause one of the officers to leave the department.

When a reformed gang member is murdered, the case takes the team back to a familiar neighborhood where they find themselves unwelcomed. Brenda must figure out a way to solve what appears to have been a missed-mark murder and bring peace to an unstable community.

Brenda must reopen the case of a murdered psychiatrist when the man claiming to have committed the crime gives a statement that doesn't quite match the actual events. Based on evidence of the man's acquaintance with the doctor, Brenda believes there is a cover-up and sets out to unearth the truth. Willie Rae throws a roadblock in her path when she pops in for a visit, which actually appears to be an attempt to dump Brenda's handful of a niece onto the newlyweds during for the duration of summer break.

Capt. Raydor (special guest star Mary McDonnell) approaches Major Crimes about delicately looking into a possible case of spousal abuse involving one of her female officers. On the home front, Fritz becomes increasingly irritated at feeling ignored by Brenda.

At the request of Detective Mikki Mendoza, the squad becomes involved in investigating a series of brutal murders that indicate a Mexican drug cartel may have moved into the city.

Brenda's parents return with surprising news that keeps Brenda's mind from her case.