Brenda and the PHD investigate the murder of a personal trainer who was involved with the wife of a possessive husband with a temper. Complicating the investigation, their only witness is the man's frightened valet, who also has OCD.

When a 12-year-old disappears, Brenda must decide whether to treat him as a runaway or a missing person.

The body of a man who stole $3 million in diamonds is found in the trunk of a car and the condition of the body makes determining the cause of death impossible.

Sgt. Gabriel comes under investigation for shooting a homicide suspect when the facts don't add up. The internal investigation gets in the way of the original murder investigation, leaving the entire team tied up in knots.

The team digs through several suspects that surface after a man's body is found inside an oversized box. Brenda finds the case the perfect platform to play the role of teacher to Gabriel as he prepares for his detective exam. When Brenda's niece, Charlie, gets out of hand, she and Fritz must consider ending her summer vacation with them.

Capt. Raydor (special guest star Mary McDonnell) approaches Major Crimes about delicately looking into a possible case of spousal abuse involving one of her female officers. On the home front, Fritz becomes increasingly irritated at feeling ignored by Brenda.

After a parole board member is viciously murdered during a panicked phone call with Sgt. Gabriel, Pope announces an overreaching plan to boost the police department’s image. His plan, however, hinges on Brenda first being able to solve the crime.

The routine arrest of a crack addict exposes a questionable rehab facility and leads Brenda and her squad on a race to find a missing young woman. The case leads Gabriel to question Brenda’s judgment and Fritz to reveal to Brenda the some ugly truths about his past.

Tao's son works at a camp where a boy goes missing.

The death of a high school principal who had been trying to raise test scores at his school to prevent it from being closed causes Brenda and Fritz to fight over who has control of the case because an already existing FBI investigation causes the cases to overlap.

Investigating the death of a beloved cancer doctor hits too close to home for Brenda who's already upset after learning that Pope is monitoring everything she does.